Many children with autism have a reduced level of glutathione and a reduced ability to excrete mercury, resulting in elevated levels in their bodies as demonstrated by blood, hair, provoked urine, and baby tooth testing. Our earlier studies have demonstrated that DMSA, an FDA-approved medication for treating lead poisoning in children, is effective in increasing excretion of mercury and other toxic metals. Based on many clinical reports, we hypothesize that a 3-month treatment with glutathione and DMSA will result in a reduction of autistic symptoms in some children with autism.
Detailed Description:. This study will assess the safety and efficacy of the use of DMSA an FDA-approved medication for treating lead poisoning in children for the off-label treatment of symptoms of autism in children with autism and significant body burden of toxic metals. FDA Resources. Arms and Interventions. Outcome Measures. Secondary Outcome Measures : Determine if the initial severity of autism correlates with the excretion of toxic metals [ Time Frame: 1 month ].
Eligibility Criteria. Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Inclusion Criteria: Phase One Children with autism spectrum disorder Age years up to the day before the ninth birthday. U per day have been shown to have a protective effect when the brain is exposed to methyl-mercury.
Selenium, mcg daily, is a particularly important trace mineral in mercury elimination and should be used for most patients.
Selenium facilitates the function of glutathione, which is also important in mercury detoxification. Some clinicians find repetitive high dose intravenous glutathione useful, especially in neurologically compromised patients. There is a suggestion in a rat model that lipoic acid may also be useful, but some clinicians are concerned about the potential of lipoic acid to bring mercury into the brain early in the stages of chelation, similar to DMSA and N-acetylcysteine NAC , which has also been used in mercury chelation.
Doses larger than mg per day should be used with caution. Vitamin C is also a helpful supplement for mercury elimination as it will tend to mobilize mercury from intracellular stores. Frackelton, James P. Lyle, Ph. Address: James P. Frackelton, M. The authors have found that mercury removal therapy using DMSA in patients who exhibit chemical sensitivity from mercury poisoning has been clinically successful, using a daily dose of mg on an empty stomach every other day for a minimum of 5 weeks.
Occasionally, sensitive individuals have to have the dose reduced to mg of DMSA 3 times per week followed by an increase to mg in the same dosage after 2 to 3 weeks. Rapid responses have occurred although 4 to 5 weeks are usually needed for patients to experience a reduction in symptoms.
If patients are planning to have mercury restorations completely removed, the DMSA treatment is effective if begun just prior to removal. Many patients experience fewer mercury toxicity symptoms during amalgam removal when taking DMSA regularly 3 times a week plus an additional dose on the day of the dental procedure. Keep learning about alternative medication solutions for you, your family, and friends.
By submitting this form, you are consenting to receive marketing emails from: Harbor Compounding Pharmacy, Harbor Blvd. Suite C, Harbor Blvd. Emails are serviced by Constant Contact. Please click here if you are not redirected within a few seconds. Heavy Metal Toxicity Part Mercury exposure and toxicity is a prevalent and significant public health threat. Dental amalgams are a major source of mercury toxicity.
Systemic Mercury Elimination. Treatment options for mercury toxicity. DMPS can be used to eliminate mercury systemically. DMPS safety. EDTA capsules have another shortcoming, Shannon says. Even when properly used, chelation has its limits. E-mail the details to health latimes. All Sections. About Us. B2B Publishing. In addition, some of the companies that make chelation products also market screening tests that claim to detect the presence of heavy metals in urine to falsely justify the need for the treatment.
FDA has not cleared these tests, either. All FDA-approved chelation products require a prescription because they can only be used safely under the supervision of healthcare practitioner. Although some of these products are marketed as dietary supplements, they are, in fact, unapproved new drugs. These companies marketing unapproved OTC chelation products commonly target patients with serious and incurable diseases who may have limited treatment options. Two common conditions that these products claim to treat are autism spectrum disorders and heart cardiovascular conditions, including treatment of high blood pressure, high cholesterol, clogged arteries, angina, prevention of heart attack or stroke, and even as an alternative to coronary bypass surgery.
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