Can you spare minutes to tell us what you think of this website? Open survey. In: Facts In the Cell. This is carried out by an enzyme called helicase which breaks the hydrogen bonds holding the complementary bases of DNA together A with T, C with G. The two separated strands will act as templates for making the new strands of DNA. As a result of their different orientations, the two strands are replicated differently: An illustration to show replication of the leading and lagging strands of DNA.
Related Content:. What is a genome? What is DNA? What is a cell? How helpful was this page? What's the main reason for your rating? Which of these best describes your occupation? Boddy, M. DNA replication checkpoint. Branzei, D. Interplay of replication checkpoints and repair proteins at stalled replication forks.
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Cell Division and Cancer. Cytokinesis Mechanisms in Yeast. Recovering a Stalled Replication Fork. Aging and Cell Division. Germ Cells and Epigenetics. Citation: Noguchi, E. Nature Education 3 9 The replication fork is more than just a means for DNA duplication. It is connected to a checkpoint system that keeps the genome intact and prevents cancer. Aa Aa Aa. Figure 1: Obstacles on DNA that generate stalled replication forks.
Figure Detail. Figure 2: Checkpoint responses. Figure 3: Fork protection. Stabilizing replisome components at the replication fork when the fork stalls, so that the fork can re-start after the problems are solved.
Preventing fork breakage. If the fork is broken, fork protectors may be required to re-assemble replisome components. Protecting the replication forks in a configuration that is recognized by replication checkpoint proteins Figure 2. References and Recommended Reading Abraham, R. Article History Close. Share Cancel. Revoke Cancel. Keywords Keywords for this Article.
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